Publications
Abstracts, poster presentations and publications in the area of endotoxin related diseases including sepsis and others:
Endotoxin activity levels as a prediction tool for risk of deterioration in patients with sepsis not admitted to the intensive care unit: A pilot observational study
Emanuela Biagioni, MD , Claudia Venturelli, BS , David J. Klein, MD , Marta Buoncristiano, MS , Fabio Rumpianesi, MD , Stefano Busani, MD , Laura Rinaldi, MD , Abele Donati, MD , Massimo Girardis
Journal of Critical Care, April 2013, j.jcrc.2013.02.005
Prognostic value of endotoxin activity assay in patients with severe sepsis after cardiac surgery.
Michail Yaroustovsky, Marina Plyushch, Dmitry Popov, Natalia Samsonova, Marina Abramyan, Zakhar Popok and Nickolay Krotenko
Journal of Inflammation, March 2013, 10:8
Markers of intestinal injury are associated with endotoxemia in successfully resuscitated patients.
D. Grimaldi , E. Guivarch , N. Neveux , J. Fichet , F. Pène , J.-S. Marx , J.-D. Chiche , L. Cynober , J.-P. Mira , A. Cariou
Resuscitation Volume 84, Issue 1 , Pages 60-65, January 2013
Bench-to-bedside review: Clinical experience with the endotoxin activity assay.
Alexander D Romaschin, David J Klein and John C Marshall
Critical Care 2012, 16:248, December 2012
Increased endotoxin activity is associated with clinical deterioration in moderate-severity emergency department sepsis patients: a pilot study
R Arnold, C Schorr, S Trzeciak and RP Dellinger
Critical Care 2012, Volume 16. Supp. 3, Sepsis 2012, November 2012
Safety of Polymyxin-B–based Hemoperfusion in Kidney and Liver Transplant Recipients
Yukihiro G. Novelli, V. Morabito, G. Ferretti, L. Poli, S. Novelli, F. Ruberto, F. Pugliese, G. Mennini, M. Rossi, PB. Berloco
Transplantation Proceedings, Sept 2012
Time to Initiation of Treatment with Polymyxin B Cartridge Hemoperfusion in Septic Shock Patients
Yukihiro Takeyama N. Noguchi H. Hirakawa A. Kano H. Morino K. Obata T. Sakamoto T. Tamai F. Ishikura H.f· Kase Y. Kobayashi M. Naka T. Takahashi Y.
Blood Purification, Vol. 33, No. 4, June 2012
Impact of endotoxin measured by an endotoxin activity assay during liver transplantation
Yukihiro Sanada, MD , Koichi Mizuta, MD, PhD , Taizen Urahashi, MD, PhD , Yoshiyuki Ihara, MD, PhD , Taiichi Wakiya, MD,
Noriki Okada, MD , Naoya Yamada, MD , Kentaro Ushijima, PhD , Shinya Otomo , Koichi Sakamoto, PhD , Yoshikazu Yasuda, MD, PhD , Hideo Kawarasaki, MD, PhD
Journal of Surgical Research, May 2012
Combining intermediate levels of the Endotoxin Activity Assay (EAA) with other biomarkers in the assessment of patients with sepsis: results of an observational study
Arino Yaguchi, Junji Yuzawa, David J Klein, Munekasu Takeda and Tomoyuki Harada
Critical Care 2012, 16:R88
Clinical usefulness of measuring endotoxin activity on ICU admission
A Murai, H Ishikura, T Nishida, Y Irie, T Kamitani, R Yuge, T Kitamura and T Umemura
Critical Care 2012, 16(Suppl 1):P34
Intestinal Injury and Endotoxemia in Children Undergoing Surgery for Congenital Heart Disease
Nazima Pathan, Margarita Burmester, Tanja Adamovic, Maurice Berk, Keng Wooi Ng, Helen Betts, Duncan Macrae, Simon Waddell, Mark Paul-Clark, Rosamund Nuamah, Charles Mein, Michael Levin, Giovanni Montana, and Jane Mitchell
Am. J. Respir. Crit. Care Med. 2011
Endotoxaemia in paediatric critical illness - a pilot study
Shamik Dholakia , David Inwald , Helen Betts and Simon Nadel
Critical Care 2011, 15:R141, June 2011
Systemic Endotoxemia Following Multiple Trauma is Associated with Early Shock and Predicts Subsequent Mortality
Emmanuel Charbonney, MD, Yangmei Li, David Klein, MD, MBA, Alexander Romaschin, PhD, Avery B. Nathens, MD, PhD, John C. Marshall, MD
The 31st Annual Meeting of the Surgical Infection Society, 2011, Florida
EAA helps to detect the cause of ARDS at bedside
Junichi Kitayama, MD, Takeyuki Kiguchi, MD, Kazuma Yamakawa, MD, Yasushi Nakamori, MD, Satoshi Fujimi, MD
The 31st Annual Meeting of the Surgical Infection Society, 2011, Florida
Endotoxin Activity Assay for early diagnosis of SIRS in Acute on Chronic Liver Failure patients
Dr. Vincenzo Morabito
2011 European Association for the Study of the Liver Monothematic Conference, Nice, FR
Endotoxemia related to cardiopulmonary bypass is associated with increased risk of infection after cardiac surgery: a prospective observational study
David J Klein , Fracoise Briet , Rosane Nisenbaum , Alexander D Romaschin, C DAVID Mazer
Critical Care 2011, 15:R69, February 2011
New sepsis-related marker: endotoxin activity assay
T Ikeda, K Ikeda, H Taniuchi, M Hiramatsu and S Suda
Critical Care, September 2010, 14(Suppl 2):P12
Endotoxin Activity Assay and Polimyxyn-B in early management of endotoxemia
Novelli G., Ferretti G., Poli L., Morabito V., Ruberto f., Rossi M., Berloco P.
The Transplantation Society International Congress, August 2010
Endotoxin activity assay (EAA) and polymyxin-B hemoperfusion (PMX-DHP) – an endotoxin targeted theranostic strategy
Romaschin AD, Klein DJ, Foster D, Kruspe A
IEIIS 2010
Prognostic value of endotoxin activity assay (EAA) in complex intensive care for sepsis and septic shock in patients after cardiac surgery
M. Yaroustovsky, M. Abramian, Z. Popok, M. Plusch, E. Nazarova, O. Stupchenko
ESICM 2010 E-Poster
Selective hemoperfusion in complex intensive care for severe sepsis and septic shock in patients after cardiac surgery
M. Yaroustovsky, M. Abramyan, Z. Popok, D. Popov, M. Plusch, E. Nazarova, O. Stupchenko
ESICM 2010 E-Poster
Correlation between gut injury and endotoxinemia following resuscitation from a cardiac arrest
D. Grimaldi, E. Guivarch, N. Neveux, B. Zuber, N. Demars, C. Rousseau, J.-S. Marx, J.-D. Chiche, A. Cariou.
ESICM 2010 E-Poster
Endotoxemia and Endotoxin Shock: Disease, Diagnosis and Therapy
Editors: Claudio Ronco, Vicenza, Pasquale Piccinni, Vicenza, Mitchell H. Rosner, Charlottesville, VA. Contributions to Nephrology, Vol. 167, 2010 Available from Karger Publishing
Prevalence of endotoxemia after surgery and its association with ICU length of stay
Franco Valenza, Lorella Fagnani, Silvia Coppola, Sara Froio, Francesca Sacconi, Cecilia Tedesco, Micol Maffioletti, Marta Pizzocri, Valentina Salice, Maria LUISA Ranzi, Cristina Marenghi and Luciano Gattinoni.
Critical Care 2009, 13:R102, June 2009
Early Use of Polymyxin B Hemoperfusion in Abdominal Septic Shock The EUPHAS Randomized Controlled Trial
Dinna N. Cruz, MD, MPH; Massimo Antonelli, MD; Roberto Fumagalli, MD; Francesca Foltran, MD; Nicola Brienza, MD, PhD; Abele Donati, MD; Vincenzo Malcangi, MD; Flavia Petrini, MD; Giada Volta, MD; Franco M. Bobbio Pallavicini, MD; Federica Rottoli, MD; Francesco Giunta, MD; Claudio Ronco, MD.
JAMA. 2009;301(23):2445-2452. June 2009
Endotoxemia is common following abdominal organ transplantation and is associated with reperfusion and rejection.
Ibtesam Hilmi, John A. Kellum, Raymond Planinsic, Debra Foster, Ali Abdullah, Daniela Damian, Silviu Gligor, David Klein, Kareem Abu-Elmagd. Journal of Organ Dysfunction, March 2009.
Newly Developed Endotoxin Measurement Method (Endotoxin Activity Assay) May Reflect the Severity of Sepsis. Murayama, Y Kakihana, T Oryoji, N Kiyonaga, S Tashiro, T Imabayashi, T Yasuda and Y Kanmura, Kagoshima University Hospital, Kagoshima, Japan.
Poster Presentation From 29th International Symposium on Intensive Care and Emergency Medicine, Brussels, Belgium. 24–27 March 2009
Endotoxemia as a Biomarker in Early Sepsis: Experience from Europe and North America.
Foster, Debra; Abstract - 11th Annual Congress of Endotoxemia in Critical Illness, Fukouka, Japan, February, 2008
Clinical Usefulness of a Newly Developed Whole Blood Endotoxin Assay (EAA).
Atagi Kazuaki, Shimaoka Hideki, and Nishi Shinichi. ICU and CCU-Japanese Journal of Intensive Care Medicine, Vol. 31, No. 6, 445-452, 2007.
Efficacy and Problem of a New Endotoxin Activity Assay Method.
Endo Shigeatsu, Sato Nobuhiro, Suzuki Yasushi, Kojika Masahiro, Takahashi Gaku, Yaegashi Yasunori
ICU and CCU-Japanese Journal of Intensive Care Medicine, Vol. 31, No. 6, 407-410, 2007
Diagnostic and Prognostic Implications Endotoxemia Based on Measurements Using the Endotoxin Activity Assay.
Walker Paul M., Japanese J. of Critical Care Endotoxemia, Vol. 11, No.1, 9-25, 2007
Endotoxemia: Insights from a New Method for Measurement in Human Whole Blood.
Foster Debra M., Japanese J. of Critical Care Endotoxemia, Vol. 11, No.1, 121-126, 2007.
Patients with Chronic Kidney Disease (CKD) stage 3-5 have Endotoxin levels similar with ICU patients with sepsis.
Levine Daniel, Parker Thomas, Bologa Roxana, Gordon Bruce, Foster Debra, Walker Paul, Klein David
Abstract - ASN Renal Week 2007, San Francisco, CA
Daily Variation in Endotoxin Levels is Associated with Increased Organ Failure in Critically Ill Patients.
Klein DJ, Derzko A, Foster D, Seely A, Brunet F, Romaschin A, Marshall JC.
Shock, November 2007
Endotoxin Levels as a Marker for Liver Graft Performance in Patients Undergoing Liver Transplantation.
Hilmi, RM Planinsic, Daniela Damian, Testsuro Sakai, Nizar Moayeri.
Abstract Presented at ASA Annual Meeting, San Francisco California, Oct. 2007
Endotoxin Concentration Following Cardiac Surgery with Cardiopulmonary Bypass.
Kagoshima University ICU.
Abstract Presented at ASA Annual Meeting, San Francisco California, October, 2007
Endotoxin activity in whole blood measured by neutrophil chemiluminescence is applicable to canine whole blood.
Mads Kjelgaard-Hansen, Bo Wiinberg, Bent Aalbæk, Lisbeth Olsen, David Harris, Alexander Romaschin, Annemarie T. Kristensen and Asger L. Jensen. Comparative Immunology, Microbiology and Infectious Diseases, August 2007
Endotoxemia in pediatric critical illness.
S. Nadel, 5th World Congress on Pediatric Critical Care, Geneva Switzerland, June, 2007
Prevalence of Endotoxemia in a population of patients admitted to an intensive care unit after elective surgery.
F. Valenza, L. Fagnani, S. Coppola, L. Gattinoni et al.
27th International Symposium on Intensive Care and Emergency Medicine, Critical Care, Vol 11 Suppl2, March 2007
Patterns of Endotoxemia in a Paradigm of Early Goal Directed Therapy
Ronny M. Otero, Arturo Suarez, Steadman S. Sankey and Emanuel Rivers,
26th annual meeting of the Society of Critical Care Medicine, Orlando, FL February 2007
Hemodialysis patients have Endotoxin activity levels comparable to critically ill patients.
Bologa, Roxana M. Levine, Daniel M. Parker, Thomas S. Gordon, Bruce R. Foster, Debra Walker, Paul Klein, David J., 25th annual meeting of the Society for Critical Care Medicine, January 6, 2006, San Francisco, CA
Endotoxemia is a marker of adverse outcomes in patients with Gram positive as well as Gram negative infection on admission to the Intensive Care Unit.
David J Klein, Debra Foster, Anastasia Derzko, John C Marshall, Toronto Critical Care Medicine Meeting, October 30, 2005.
A comparison of the rates of agreement for assays of endotoxin (EAA) procalcitonin (PCT) and lactate in septic and non-septic critically ill patients.
Alex Romaschin, Anastasia Derzko, Debra Foster, David Klein, Paul Walker.
25th International Symposium of Intensive Care and Emergency Medicine, Brussels Belgium, March 22-25, 2005.
Marker or Mediator: Changes in endotoxin activity as a predictor of adverse outcomes in critical illness.
Klein DJ, Derzko A, Seely A, Foster D and Marshall JC.
25th International Symposium on Intensive Care and Emergency Medicine Brussels, Belgium. 21–25 March 2005
A Comparison of the rates of agreement for assays of Endotoxin, procalcitonin and lactate in septic and non-septic critically ill patients.
A. Romaschin, J. Marshall, D. Klein. D. Foster.
American Association of Clinical Chemists, Los Angeles, California. July 2005.
A Novel Method for rapid detection of human endotoxemia.
Foster DM, Derzko AN & Romaschin AD. Clinical Laboratory International, April 2004.
Diagnostic and Prognostic Implications of Endotoxemia in Critical Illness: Results of the MEDIC Study.
JC Marshall, D Foster, JL Vincent, DJ Cook, et al.
Journal of Infectious Diseases, Aug. 2004.
Can Sepsis be better defined? Contribution of a novel assay for endotoxin.
Foster DM, Derzko AN & Keffer JH.
Clinical Microbiology Newsletter 26: 3, 2004
Measurement of endotoxin activity in critically ill patients using whole blood neutrophil dependent chemiluminescence.
Marshall JC, Walker PM, Foster DM, et al.
Critical Care 2002; 6(4): 342-348
A rapid assay of endotoxin in whole blood using autologous neutrophil dependent chemiluminescence.
Romaschin AD, Harris DM, Ribeiro MB, et al.
J. Immunol. Methods 1998; 212: 169-185.
Let the Cells Speak: neutrophils as biologic markers of the inflammatory response.
Romaschin AD, Foster DM, Walker PM, Marshall JC., Sepsis 1998; 2: 119-125.